A city that ran a farm
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منابع مشابه
Ran at a glance.
Ran is an abundant Ras-like GTPase that was initially characterized for its role in modulating the nucleo-cytoplasmic transport of macromolecules across the nuclear envelope (NE). However, it is also critical for other cellular processes, including mitotic spindle assembly and post-mitotic nuclear envelope assembly. Several excellent reviews detail its role in these diverse processes (Gruss and...
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متن کاملRan
How is Ran involved in nuclear transport? Cargo is transported through pores in the nuclear envelope, in association with carriers that bind to pore proteins called nucleoporins. A Ran–GTP gradient across the envelope is created by the asymmetric distribution of the GTPase activating protein known as RanGAP, which is in the cytosol, and of the guanine nucleotide exchange factor RanGEF in the nu...
متن کاملRan/TC4: a small nuclear GTP-binding protein that regulates DNA synthesis
Ran/TC4, first identified as a well-conserved gene distantly related to H-RAS, encodes a protein which has recently been shown in yeast and mammalian systems to interact with RCC1, a protein whose function is required for the normal coupling of the completion of DNA synthesis and the initiation of mitosis. Here, we present data indicating that the nuclear localization of Ran/TC4 requires the pr...
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ژورنال
عنوان ژورنال: National Municipal Review
سال: 1920
ISSN: 0190-3799,1931-0250
DOI: 10.1002/ncr.4110090204